Bhasani was born in 1880 at village Dhanpara of Sirajganj district.
Maulana Abdul Hamid Khan Bhasani (1880-1976) was a religious personality and politician. He is popularly known as Maulana Bhasani. He was self-educated, village-based, a fire-brand, and skeptical about colonial institutions. Though immensely influential throughout his political career and instrumental in winning many general and local government elections since 1946, he consistently stayed away from holding actual power. His leadership was rooted in his relentless and incessant struggle for safeguarding the rights and interests of the peasantry and the laboring classes.

His father was Haji Sharafat Ali Khan. Apart from a few years of education at the local school and madrasa, he did not receive much formal education. He began his career as a primary school teacher at Kagmari in Tangail and then worked in a madrasa at village Kala (Haluaghat) in Mymensingh district.

In 1919, Bhasani joined the Non-cooperation Movement and Khilafat Movement to mark the launching of his long and colorful political career. He went to Santosh in Tangail to take up the leadership of the oppressed peasants during the Great depression period. From Tangail he moved to Ghagmara in Assam in the late 1930s to defend the interests of Bangali settlers there. He made his debut as a leader at Bhasan Char on the Brahmaputra where he constructed an embankment with the co-operation of the Bangali settlers, thereby saving the peasants from the scourge of annual inundation. Relieved of the recurring floods the local people fondly started to call him 'Bhasani Saheb', an epithet by which the Maulana has been known from then on.

In 1937 Bhasani joined the Muslim League and became president of Assam unit of the party. At partition, Maulana Bhasani was in Goalpara district (Assam) organizing the farmers against the line system. He was arrested by the government of Assam, and released towards the end of 1947 on condition that he would leave Assam for good.

Early in 1948 Maulana Bhasani came to East Bengal only to find himself brushed aside from the provincial leadership set-up. Disheartened, Bhasani contested and won a seat in the provincial assembly from south Tangail in a by-election defeating Khurram Khan Panni, the Muslim League candidate and zamindar of Karatia. But the provincial governor nullified the results on grounds of foul play in the elections, and disqualified all the candidates from taking part in any election until 1950.

In 1949 he went to Assam again, and was arrested and sent to Dhubri prison. On his release he came back to Dhaka. At about this time, the East Pakistan Muslim League was passing through a leadership crisis. The discontented elements of the Muslim League called a workers' convention in Dhaka on June 23 and 24 of 1949. Nearly 300 delegates from different parts of the province attended the convention. On June 24 a new political party, the East Pakistan Awami Muslim League, was launched with Maulana Bhasani as president and Shamsul Huq of Tangail as general secretary.
On the day of its birth, the party held its first public meeting at Armanitola in Dhaka under the chairmanship of Bhasani. After its second meeting in the same venue on October 11, he and many other leaders of the new party were arrested while heading a procession of hunger strikers moving towards the government secretariat to protest against the famine conditions prevailing in the province. When his life was at risk due to his protracted hunger-strike, Bhasani was released from jail in 1950.

On 21 February 1952 several students taking part in the language movement were killed in a police firing in Dhaka. Bhasani strongly condemned the brutality of the government. He was arrested on February 23 from his village home and sent behind the bar. In the politics of East Bengal in the early 1950s Bhasani emerged as the most vocal and respected politician of the time. As president of the Awami Muslim League, Bhasani played the crucial role in forging a unity among five opposition political parties by forming an alliance called the united front. In the elections held in March 1954 the United Front won 223 seats as against the Muslim League's 7 seats.

He became president of the Adamjee Jute Mills Mazdoor Union and the East Pakistan Railway Employees League. The Maulana was made to preside over two massive workers's rallies organized by the communists on May Day in 1954 in Dhaka and Narayanganj. The same year he was made president of the East Pakistan Peasants' Association. Soon after, he was made president of the East Pakistan chapter of the communist-dominated International Peace Committee. In that capacity, he went to Stockholm to attend the World Peace Conference in 1954.

In 1957 he formed a new party, called the National Awami Party (NAP), with himself as president and Mahmudul Huq Osmani from West Pakistan as secretarygeneral.

Bhasani was interned once again when Pakistan's army chief General Mohammad Ayub Khan seized power in 1958. After his release from confinement in 1963, the Maulana went on a visit to China and also to Havana in 1964 to attend the World Peace Conference. In 1967 the socialist world split into pro-Soviet and pro-China blocs. The East Pakistan NAP also split with the Maulana leading the pro-China fraction.

With the beginning of the Liberation War in 1971 Maulana Bhasani took refuge in India, but he had to spend the entire period of the liberation war in confinement in Delhi. One of his first demands after return to Dhaka (22nd January, 1972) was to withdraw Indian troops from the soil of Bangladesh. On February 25 he started publishing a weekly ‘Haq Katha’ and it soon gained wide circulation. The paper was soon banned. After the parliamentary elections in 1973, the Maulana started a hunger strike to protest against the food crisis, rise of price of essential commodities, and deteriorating law and order situation.
In 1974 Bhasani founded Hukumat-e-Rabbania order and declared a zihad or holy war against the Awami League government and Indo-Soviet overlord-ship. In April 1974 a 6-party united front was formed under the Maulana's leadership. On June 30 the Maulana was arrested and interned at Santosh in Tangail. On 16th May, 1976 he led a long march from Rajshahi towards India's Farakka Barrage to protest against plans to deprive Bangladesh of its rightful share of the Ganges waters. On 2nd October, 1976 he formed a new organization, Khodai Khidmatgar, and continued to work for his Islamic University at Santosh. He also set up

He had earlier set up 30 educational institutions in Assam.

He died on 17 November 1976 and was buried at Santosh.